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Количество страниц: 4 с.
Autosomal recessive deafness type 1A is one of the most frequent hereditary diseases in the Republic Sakha (Yakutia). The revealed features of the spectrum and frequency of pathogenic variants in the GJB2 gene in patients with congenital hearing impairment allow introducing routine DNA diagnostics into medical practice. The article discusses some of the bioethical issues of DNA testing of autosomal recessive deafness 1A type.
Некоторые биоэтические вопросы молекулярно-генетической диагностики аутосомно-рецессивной глухоты 1А типа, распространенной в якутской популяции / С. К. Кононова, Н. А. Барашков, В. Г. Пшенникова, А. В. Соловьев, А. М. Чердонова, А. А. Никанорова, Г. П. Романов, Э. К. Хуснутдинова, С. А. Федорова, Ф. М. Терютин // Якутский медицинский журнал. — 2018. — N 2 (62). — С. 79-82 — DO: 10.25789/YMJ.2018.62.23.
DOI: 10.25789/YMJ.2018.62.23
Количество страниц: 4 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Лекарствоведение. Фармакология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина.
Morphometric changes in the seminal vesicles of rats of the reproductive period under conditions of prolonged systemic immunosuppression were studied. Reliable changes in the organometric parameters of the organ were detected both at the early (7, 15 days) and at the later periods of observation, which indicates the direct effect of cyclophosphamide on the biosynthetic processes in the organ. Micromorphometric changes, as well as the results of cyto– and karyometry, confirm the organometric data and indicate the development of local disorders in the morphogenesis of seminal vesicles caused by the dysregulation of the endocrine-immune organ homeostasis.
Измерения строения семенных пузырьков крыс репродуктивного периода в условиях циклофосфамид-индуцированной иммуносупрессии / С. А. Кащенко, А. А. Захаров // Якутский медицинский журнал. — 2018. — N 2 (62). — С. 76-78 — DO: 10.25789/YMJ.2018.62.22.
DOI: 10.25789/YMJ.2018.62.22
Количество страниц: 4 с.
The effect of dihydroquercetin (DHA) bioflavonoid in a dose of 50 mg/kg on DNA synthesis and the state of the nucleo-nucleolar apparatus of white rat cardiomyocytes on an intact background and under conditions of oxidative stress was studied. The corrective effect of DHA on biosynthetic processes in the myocardium of white rats in the presence of oxidative stress was revealed. The effect of DHA on an intact background inhibits DNA synthetic processes in the myocardium of newborn animals and reduces the size of nuclei and nucleoli in cardiomyocytes of sexually mature animals. The obtained data make it possible to recommend the use of antioxidants in cardiology only in the presence of pronounced oxidative stress.
Биосинтетические процессы в кардиомиоцитах белых крыс после введения биофлавоноида дигидрокверцетина / Е. Н. Сазонова, Д. В. Яковенко, О. А. Лебедько, А. Ю. Марочко, С. Л. Жарский, В. А. Добрых, М. Ф. Рзянкина, Т. В. Чепель // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 109-112 – DO:10.25789/YMJ.2018.63.36.
DOI: 10.25789/YMJ.2018.63.36
Количество страниц: 4 с.
In order to study the features of immunity in children with multiple papillomas and the effectiveness of therapy with groprinosin and lycopid drugs, a group of children with multiple papillomas and a group of healthy children, comparable in age, were examined. All children showed a positive PCR for HPV, a histological examination of the papillomas, as well as an examination of the immune status were done. It was revealed that in children with papillomas the content of IgA, CD19 + and CD16 + lymphocytes was reduced. The therapy with groprinosin and lycopid medications leads to normalization of the lowered immune status indicators, as well as to the cessation of the appearance of new papillomas in children.
Изучение особенностей иммунитета у детей с множественными папилломами / О. Н. Иванова, Е. Ф. Аргунова, Т. Г. Дмитриева, Я. А. Мунхалова, В. Б. Егорова, С. Н. Алексеева // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 107-109 – DO: 10.25789/YMJ.2018.63.35.
DOI: 10.25789/YMJ.2018.63.35
Количество страниц: 4 с.
The article reflects the experience of transfusion therapy in major obstetric bleeding during cesarean section among women with placenta percreta from 2016 to 2018. A comparative analysis of the applied blood components and blood products is presented in the article. The analysis has shown that integration of The European guidelines on management of major bleeding allows decreasing of the average volume of blood loss, reducing postoperative transfusions, reducing the frequency of postoperative mechanical ventilation, as well as reducing the time of stay in the resuscitation department.
Опыт внедрения европейского протокола массивной кровопотери при оперативном родоразрешении у женщин с вращением плаценты / М. Б. Куцый, М. С. Карасев, Н. Ю. Владимирова, В. С. Гороховский, И. А. Стадникова, Н. В. Гришина, А. В. Серебренников // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 105-107 – DO: 10.25789/YMJ.2018.63.34.
DOI: 10.25789/YMJ.2018.63.34
Количество страниц: 4 с.
The article represents the results of medical and statistical analysis of abortion in the Sakha Republic (Yakutia) for the long-term period (1991–2015). A decrease in the incidence of abortion and transformation of its structure has been noted. The level of abortions due to social indications and registered criminal abortions has decreased the most. An increase in the proportion of spontaneous and unspecified abortions in total ratio of abortion has been found out. The results of the correlation analysis confirm the influence of the women reproductive behavior on demographic processes in the Sakha Republic (Yakutia).
Медико-статистические аспекты изучения распространенности абортов в Республике Саха (Якутия) / А. А. Яворский // Якутский медицинский журнал. — 2018. — N 3 (63). — С. 102-105 — DO: 10.25789/YMJ.2018.63.33.
Количество страниц: 4 с.
The article presents the clinical case of management of a child with a genetic metabolic disease until setting a correct diagnosis propionic acidemia. The full – term child aged 11 days had developed metabolic crisis, which was taken as an expression of neonatal pathology, such as neonatal jaundice, perinatal CNS lesion. On a background of detoxification the patient had the clinical positive dynamics, but a bright period lasted only two weeks. Due to a main disease the child had secondary immunodeficiency, which resulted in recurrent pneumonias. The patient was examined in three ways: changes of peripheral blood – leukopenia, thrombocytopenia, anemia; neurological symptoms – soporous condition, lethargy, refusal of meals, oppression of all reflexes, muscular hypotension; in view of anamnesis, impossibility of a comparison all the clinical symptoms to one diagnosis tap genetic research. The lack of the methodology of tandem mass spectrometry extended the time of correct diagnosis and timely treatment.
Клинический случай пропионовой ацидемии / С. Н. Алексеева, А. Л. Сухомясова, Г. И. Софронова, З. П. Андросова, С. А. Кондратьева, Е. Е. Гуринова, П. В. Павлова // Якутский медицинский журнал. — 2018. — N 3 (63). — С. 99-102 – DO: 10.25789/YMJ.2018.63.32 .
DOI: 10.25789/YMJ.2018.63.32
Количество страниц: 4 с.
Lipid peroxidation of native people and non-native residents in Yakutia was compared. The obtained data clearly indicate existence of lengthening of the adaptation phase under modern socio-economic conditions of life of the population of Yakutia compared to similar studies of the several decades before. It is likely that adaptation to the harsh conditions of the North is associated with the activation of an antioxidant-responsive element that induces the expression of proteins responsible for maintaining internal homeostasis.
Показатели перекисного окисления липидов в организме приезжих жителей Якутии / В. М. Николаев, С. И. Софронова, Л. Д. Олесова, С. Д. Ефремова, А. С. Гольдерова, Ф. В. Винокурова, Е. Д. Охлопкова, Л. И. Константинова, А. И. Яковлева, А. В. Ефремова, Е. К. Румянцев, К. М. Степанов, А. А. Григорьева, Н. К. Чирикова, А. С. Попова, С. А. Федорова // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 60-63. — DOI: 10.25789/YMJ.2019.68.16.
DOI: 10.25789/YMJ.2019.68.16
Количество страниц: 4 с.
We determined the contribution of the endocrine system to the formation of neurotic, stress-related disorders in order to identify the criteria for predicting their protracted course. A comprehensive clinical-psychopathological and hormonal examination of women with various types of the course of neurotic, stress-related disorders was performed. A psychopathological study of patients showed that overexertion of protective mental mechanisms associated with the impact of a stressful situation can lead to a breakdown in adaptation, disturbances of normal functioning and the emergence of various neurotic symptoms. We determined the hormonal criteria for predicting a protracted course of neurotic, stress-related disorders with the formation of a persistent personality changes at an early stage of the disease - at the stage of disorder of adaptive reactions.
Возможности прогнозирования течения невротических, связанных со стрессом расстройств, на основе гормональных показателей / В. Б. Никитина, О. Э. Перчаткина, М. М. Аксенов,А. К. Костин // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 51-54. – DOI: 10.25789/YMJ.2019.68.13.
DOI: 10.25789/YMJ.2019.68.13
Количество страниц: 3 с.
The paper presents an original method for determining the degree of impaired evacuation function of the stomach in patients with duodenal ulcer stenosis. The method includes conducting daily intragastric pH monitoring, counting the number of duodenogastric refluxes and determining the values of the indicators: "the ratio of pH in the body of the stomach to the pH in the antrum of the stomach", "the variation of pH in the cardiac section of the stomach", and the calculation of prognostic factors. The accuracy of determining the degree of violation of the evacuation function of the stomach of the claimed method was 92%.
Способ определения степени нарушения эвакуаторной функции желудка у больных с рубцово-язвенным стенозом двенадцатиперстной кишки / П. М. Косенко, С. А. Вавринчук, А. И. Попов, Н. В. Ташкинов, Н. И. Бояринцев, Г. Д. Сунозова // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 45-47. – DOI: 10.25789/YMJ.2019.68.11 .
DOI: 10.25789/YMJ.2019.68.11